A recent study from the Molecular Neurodegeneration lab led by Wiep Scheper (FGA) has been published in Science Advances. In this work first author Jasper Smits and colleagues from FGA and MCN elucidated a previously unknown intrinsic resilience mechanism against tau aggregation in neurons.
Brain disorders caused by mutations in single genes often present unexplained large symptom diversity. The new study shows that non-linear genetic interactions between two or more functionally related genes, STXBP1 and SNAP25, causes extreme phenotypic diversity. The study is published in Molecular Psychiatry.
Networks of nerve cells in our brain process information at high speed. Some cells transfer more than 100 signals per second to the next cell in the circuit by contact points between them, the synapses. Neuroscientists from the CNCR discovered how mobility of molecules on the receiving side of synapses support information processing.
The CNCR focuses on the mechanistic understanding of gene function in the context of cognitive function.
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