RESEARCH FOCUS
In the “Neuronal Oscillations and Cognition Group”, we perform conceptual, theoretical, and empirical research on neuronal oscillations in health and disease. As a working hypothesis, we consider oscillations important for cognition. Our goal is to explain why and how.
Our thinking of “brain and cognition” is influenced by progress in understanding the role of self-organization in non-linear systems for the emergence and character of complexity in nature. The evidence suggests that many natural systems are attracted to a so-called “critical state”, which is characterized by correlated fluctuations on many spatial and temporal scales. Interestingly, not only are the generic mechanisms of self-organized critical systems present in neuronal networks, but the critical state may also be beneficial for optimal information processing.
Therefore, we explore the framework of criticality to study ongoing neuronal oscillations and cognition. However, is brain and cognition not to be studied in the context of sensory stimuli? Not necessarily. Oscillations come and go - thoughts come and go. In fact, the prevalence of mind wandering in everyday life, and the high heritability of ongoing brain activity and complex cognitive traits, suggest that it is fundamentally important to understand the endogenous variation in brain and cognition. Of note, brain-related disorders tend to impact endogenous cognition more so than sensory processing. These are some of the reasons why we focus on developing experimental paradigms, computational models, and biomarkers to better understand variation in endogenous oscillations and cognition.
Last Key Publications
Smit DJA, de Geus EJC, van de Nieuwenhuijzen ME, van Beijsterveldt CEM, van Baal GCM, Mansvelder HD, Boomsma DI, Linkenkaer-Hansen K. Scale-free modulation of resting-state neuronal oscillations reflects prolonged brain maturation in humans. Journal of Neuroscience. 31(37):13128–13136, 2011.
Poil S-S, Jansen R, Timmerman J, Brussaard AB, Mansvelder HD, Linkenkaer-Hansen K. Fast network oscillations in vitro exhibit a slow decay of temporal auto-correlations. Eur J Neurosci. 34:394–403, 2011.
Montez T, Poil S-S, Jones B, Manshanden I, Verbunt JPA, van Dijk BW, Brussaard AB, van Ooyen A, Stam CJ, Scheltens P, Linkenkaer-Hansen K. Altered temporal correlations in parietal alpha and prefrontal theta oscillations in early-stage Alzheimer disease. PNAS
106:1614–1619, 2009.
Poil S-S, van Ooyen A, Linkenkaer-Hansen K. Avalanche dynamics of human brain oscillations: relation to critical branching processes and temporal correlations. Human Brain Mapping 29:770–777, 2008.
Linkenkaer-Hansen K, Smit DJA, Barkil A, van Beijsterveldt TEM, Brussaard AB, Boomsma DI, van Ooyen A, de Geus EJC. Genetic contributions to long-range temporal correlations in ongoing oscillations. The Journal of Neuroscience. 27:13882–13889, 2007.


