Research Focus
Both glia in the peripheral nervous system (i.e. Schwann cells) and central nervous system (i.e. oligodendrocytes, microglia and astrocytes) have traditionally been viewed to support neuronal functions. However, in several brain regions glial cells outnumber neurons by far, suggesting that glial cells may do more than just supporting neuronal function. Our research aims to contribute to a better understanding of the role of glial cells, with a focus on the role of glial-derived lipids in the regulation of neuronal plasticity in health and disease. For this purpose, experiments are being performed both in vitro (e.g. neuron-glial cell cocultures) and in vivo (e.g. mouse transgenics).

Research line: Myelin membrane biogenesis
The rapid saltatory conduction of neuronal action potentials is crucially dependent on the insulating glial myelin membrane. The electrical insulating property of the myelin membrane is provided by its high and characteristic lipid content. Accordingly, lipid metabolic disorders often produce myelin defects. We recently identified SREBP transcription factors as important regulators of myelin lipid synthesis. Current research aims to understand how coordinated expression of proteins and lipids for the myelin membrane is regulated, and the role of myelin lipids in functioning of the brain in health and disease.

Research line: Astrocytes & synapse formation and function
In recent years an intriguing representation of the synapse has emerged in which astrocytes and neuronal synaptic elements function together as active partners in the modulation of synaptic transmission. We aim to address the role of glial-derived factors, especially lipids, in the formation and function of synapses.